Publications
Listed in chronological order.
Park SL, Christo SN, Wells AC, Gandolfo LC, Zaid A, Alexandre YO, Burn TN, Schröder J et al. Divergent molecular networks program functionally distinct CD8+ skin-resident memory T cells. Science. 2023 Dec. 382(6674): 1073-1079.
Wong A, Devason AS, Umana IC…Park SL, Wisser S, McKnight AD et al. Serotonin reduction in post-acute sequelae of viral infection. Cell. 2023 Oct. 186(22).
Gebhardt T, Park SL, Parish I. Stem-like exhausted and memory CD8+ T cells in cancer. Nature Reviews Cancer. 2023 Oct. 23:780–798.
Evrard M, Becht E, Fonseca R, Obers A, Park SL, Ghabdan-Zanluqui N, Schroeder J, Christo SN, Schienstock D et al. Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts. Immunity. 2023 Jul 56(7):1664-1680
Baxter AE, Huang H, Giles JR, Chen, Z, Wu JE, Drury S, Dalton K, Park SL, Torres L, Simone BW et al. The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells. Immunity. 2023 Jun 56(6)
Osman M, Park SL, Mackay LK. Tissue-resident memory T (TRM) cells: Front-line workers of the immune system. European Journal of Immunology. Jan 2023.
Fonseca R, Burn TN, Gandolfo C, Devi S, Park SL, Obers A, Evrard M, Christo SN, Buquicchio FA, et al. Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells. Nature Immunology. 2022 Jul 23: 1236–1245.
Park SL, Christo SN, Mackay LK. ICOS-play: dressing T cells for residency. Trends in Immunology. 2022 Mar 43(4): 280-282.
Evrard M, Wynne-Jones E, Peng C, Kato Y, Christo SN, Fonseca R, Park SL, Burn TN, Osman M, Devi S, Chun J, Mueller SN, Kannourakis G, Berzins SP, Pellicci DG, Heath WR, Jameson SC, Mackay LK. Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes. The Journal of Experimental Medicine. 2022 Jan 3;219(1):e20210116. doi: 10.1084/jem.20210116. Epub ahead of print 2021 Oct 22.
Christo SN, Evrard M, Park SL, Gandolfo LC, Burn TN, Fonseca R, Newman DM, Alexandre YO, Collins N, Zamudio NM, Souza-Fonseca-Guimaraes F, Pellicci DG, Chisanga D, Shi W, Bartholin L, Belz GT, Huntington ND, Lucas A, Lucas M, Mueller SN, Heath WR, Ginhoux F, Speed TP, Carbone FR, Kallies A, Mackay LK. Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity. Nature Immunology. 2021 Sep;22(9):1140-1151. doi: 10.1038/s41590-021-01004-1.
Hochheiser K, Wiede F, Wagner T, Freestone D, Enders MH, Olshansky M, Russ B, Nüssing S, Bawden E, Braun A, Bachem A, Gressier E, McConville R, Park SL, Jones CM, Davey GM, Gyorki DE, Tscharke D, Parish IA, Turner S, Herold MJ, Tiganis T, Bedoui S, Gebhardt T. Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin. The Journal of Experimental Medicine. 2021 Jun 7;218(6):e20200940. doi: 10.1084/jem.20200940.
Park SL, Mackay LK. Decoding Tissue-Residency: Programming and Potential of Frontline Memory T Cells. Cold Spring Harbour Perspectives in Biology. 2021 Oct 1;13(10):a037960. doi: 10.1101/cshperspect.a037960.
Alexandre YO, Devi S, Park SL, Mackay LK, Heath WR, Mueller SN. Systemic Inflammation Suppresses Lymphoid Tissue Remodeling and B Cell Immunity during Concomitant Local Infection. Cell Reports. 2020 Dec 29;33(13):108567. doi: 10.1016/j.celrep.2020.108567.
Frizzell H, Fonseca R, Christo SN, Evrard M, Cruz-Gomez S, Zanluqui NG, Von Scheidt B, Freestone D, Park SL, McWilliam HEG, Villadangos JA, Carbone FR, Mackay LK. Organ-specific isoform selection of fatty acid–binding proteins in tissue-resident lymphocytes. Science Immunology. 2020 Apr 3; 5(46). DOI: 10.1126/sciimmunol.aay9283
Trubiano JA, Gordon CL, Castellucci C, Christo SN, Park SL, Mouhtouris E, Konvinse K, Rose M, Goh M, Boyd AS, Phillips EJ, Mackay LK. Analysis of Skin-Resident Memory T Cells Following Drug Hypersensitivity Reactions. Journal of Investigative Dermatology. 2020 Jul;140(7):1442-1445.e4. doi: 10.1016/j.jid.2019.11.020. Epub 2019 Dec 26.
Wiede F, Lu KH, Du X, Liang S, Hochheiser K, Dodd GT, Goh PK, Kearney C, Meyran D, Beavis PA, Henderson MA, Park SL, Waithman J, Zhang S, Zhang ZY, Oliaro J, Gebhardt T, Darcy PK, Tiganis T. PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours. EMBO Journal. 2020 Jan 15;39(2):e103637. doi: 10.15252/embj.2019103637. Epub 2019 Dec 5.
Park SL, Mackay LK. Bhlhe40 Keeps Resident T Cells Too Fit to Quit. Immunity. 2019 Sep 17;51(3):418-420. doi: 10.1016/j.immuni.2019.08.016
Park SL, Gebhardt T, Mackay LK. Tissue-Resident Memory T Cells in Cancer Immunosurveillance. Trends in Immunology. 2019 Aug;40(8):735-747. doi: 10.1016/j.it.2019.06.002. Epub 2019 Jun 26.
Park SL, Mackay LK, Waithman J, Gebhardt T. Tissue-resident memory T cells orchestrate tumour-immune equilibrium. Cell Stress. 2019 Apr 26;3(5):162-164. doi: 10.15698/cst2019.05.187.
Mielke LA, Liao Y, Clemens EB, Firth MA, Duckworth B, Huang Q, Almeida FF, Chopin M, Koay HF, Bell CA, Hediyeh-Zadeh S, Park SL, Raghu D, Choi J, Putoczki TL, Hodgkin PD, Franks AE, Mackay LK, Godfrey DI, Davis MJ, Xue HH, Bryant VL, Kedzierska K, Shi W, Belz GT. TCF-1 limits the formation of Tc17 cells via repression of the MAF-RORγt axis. The Journal of Experimental Medicine. 2019 Jul 1;216(7):1682-1699. doi: 10.1084/jem.20181778. Epub 2019 May 29.
Park SL, Buzzai A, Rautela J, Hor JL, Hochheiser K, Effern M, McBain N, Wagner T, Edwards J, McConville R, Wilmott JS, Scolyer RA, Tüting T, Palendira U, Gyorki D, Mueller SN, Huntington ND, Bedoui S, Hölzel M, Mackay LK, Waithman J, Gebhardt T. Tissue-resident memory CD8 + T cells promote melanoma-immune equilibrium in skin. Nature. 2019 Jan;565(7739):366-371. doi: 10.1038/s41586-018-0812-9. Epub 2018 Dec 31.
Park SL, Zaid A, Hor JL, Christo SN, Prier JE, Davies B, Alexandre YO, Gregory JL, Russell TA, Gebhardt T, Carbone FR, Tscharke DC, Heath WR, Mueller SN, Mackay LK. Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses. 2018 Feb;19(2):183-191. doi: 10.1038/s41590-017-0027-5.Epub 2018 Jan 8.
Park SL, Mackay LK. PD-1: always on my mind. Immunology & Cell Biology. 2017 Nov;95(10):857-858. doi: 10.1038/icb.2017.69. Epub 2017 Sep 26.
Park SL, Mackay LK, Gebhardt T. Distinct recirculation potential of CD69 + CD103 - and CD103 + thymic memory CD8 + T cells. Immunology & Cell Biology. 2016 Nov;94(10):975-980. doi: 10.1038/icb.2016.60. Epub 2016 Jun 22.
